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KMID : 0380620080400050574
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Korean Journal of Food Science and Technology
2008 Volume.40 No. 5 p.574 ~ p.579
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Immunomodulatory Effects of Propolis and Fermented-propolis in BALB/c Mice
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Kim Yoon-Hee
Kwon Hyuck-Se
Kim Dae-Hwan
Park IL-Hwan
Park Sang-Jae
Shin Hyun-Kyung
Kim Jin-Kyung
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Abstract
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Propolis is the generic term for the resinous substance collected by honey bees from a variety of plant sources.
In this study, we have assessed the immunomodulatory properties of propolis (P) and fermented-propolis (FP) in BALB/c mice. Mice were subjected to gavage once a day (for 14 days) with 50, 100, 200 mg/kg body weight P, FP, or vehicle. Lymphocytes were isolated from the spleen and mesenteric lymph nodes (MLN) and the immune cell proportions, proliferative activities, and cytokine production were evaluated. The P- and FP-administration induced similar, but differential, alterations in the percentage of immune cell populations and their biological functions, including cytokine production and NK cell cytotoxicity. The proportion of CD4+ and CD8+ T cells in the spleen was increased slightly in the P- and FP-administered mice as compared to the vehicle-treated mice. In MLN, the percentage of CD4+ T cells was increased significantly in the 200 mg/kg P-treated mice. The mice which were treated with P and FP evidenced significantly increased interferon-γ and interleukin-4 production in concanavalin A-stimulated splenocytes, whereas the production of theses cytokines was not shown to be induced by P-treatment. In addition, NK cell activity was also increased dramatically by the administration of P and FP. Collectively, these findings showed that P and FP are widespectrum immunomodulators, which may modulate both innate and adaptive immune responses.
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KEYWORD
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propolis, immunomodulatory effect, cytokines, NK cell activity
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